Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments.
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Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments.
The pacemaker activity of the S-A node cell was explained by reconstructing the pacemaker potential using a Hodgkin-Huxley type mathematical model which was based on the reported voltage clamp data. In this model four dynamic currents, the sodium current iNa, the slow inward current, is, the potassium current, iK, and the hyperpolarization-activated current, ih, in addition to a time-dependent ...
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In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
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VASSALEE, MARIO. Analysis of card& pacemaker potential using a %ltage clamf3 technique. Am. J. Physiol. 210(6): 1335-1341. I g66.-Diastolic depolarization was studied by means of ccvoItage clamp” technique in short mammalian Purkinje fibers. Clamping the membrane potential at the maximal diastolic value resulted in an inward current rising with a time constant of 3 set in 5.4 mM K, indicating t...
متن کاملInfluence of calcium and magnesium ions on the sino-atrial node pacemaker activity of the canine heart.
HASHIMOTO , K., SUZUKI, Y. and CHIBA, S. Influence of Calcium and Magne sium Ions on the Sino-atrial Node Pacemaker Activity of the Canine Heart. Tohoku J. exp. Med., 1974, 113 (2), 187-196 •\ Using constant pressure perfusion technique of the canine sinus node artery, effects of changing concentrations of calcium and magnesium ions were investigated on the sino-atrial (SA) pacemaker activity. ...
متن کاملتأثیــر نیکــل بر مسدود کردن جریان یونــی گذرای کلسیمــی سلولهای گــره سینوسی ـ دهلیزی دست نخورده و سالم قلب خرگوش
The mammalian sino-atrial node is not a uniform tissue in histological and electrophysiological terms. The differences in ionic currents underlying the regional differences in electrial activity are only just beginning to be understood. One of the ionic currents it is thought to play a role in the center of sino-atrial node for action potential upstroke should be transient Ca+2 current ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 1980
ISSN: 1881-1396,0021-521X
DOI: 10.2170/jjphysiol.30.841